Bupivacaine liposome (By injection)

Exparel

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how bupivacaine works. Tell your doctor if you are using other numbing medicines (including lidocaine). You should not be given any other kind of anesthetic within 4 days after receiving this medicine.

Injectable

• Your doctor will prescribe your exact dose. This medicine is given through a needle injected into the surgical site or into the nerve endings of the brachial plexus (nerves that conduct signals to the shoulder, arm, and hand).
• A nurse or other health provider will give you this medicine.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Bupivacaine Liposome (bue-PIV-a-kane LYE-poh-some)

Relieves pain after surgery. This medicine is a local anesthetic.

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Anxiety, depression, restlessness, drowsiness, ringing in your ears, blurred vision
• Chest pain that may spread to your arms, jaw, back, or neck, fast, pounding, slow, or uneven heartbeat, trouble breathing
• Joint pain, stiffness, or loss of motion of the shoulder
• Lightheadedness, dizziness, fainting
• Nausea, vomiting, chills, metallic taste in your mouth
• Seizures, shivering, shaking, or tremors

If you notice these less serious side effects, talk with your doctor:

• Constipation
• Headache, back pain
• Trouble sleeping

• Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, or heart or blood vessel problems.
• This medicine may cause the following problems:
  • Heart or blood vessel problems, including changes in heart rhythm, low blood pressure, or heart attack
  • Chondrolysis (a bone or joint problem)
  • Seizures
• This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
• This medicine should cause numbness only to the area where it is injected. It is not meant to cause you to fall asleep or become unconscious.
• It may be easier to hurt yourself while your treated body area is still numb. The effects of this medicine may last up to 5 days. Be careful to avoid injury until you have regained all the feeling and are no longer numb.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.