Ketorolac (By injection)

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Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• You should not receive this medicine if you are using probenecid or pentoxifylline.
• Do not use any other NSAID medicine unless your doctor says it is okay. Some other NSAIDs are aspirin, diclofenac, ibuprofen, and naproxen.
• Some medicines can affect how ketorolac works. Tell your doctor if you are also using lithium, methotrexate, thiothixene, or alprazolam.
• Also tell your doctor if you are using a blood thinner (such as warfarin), a steroid medicine, a diuretic or "water pill" (such as furosemide, hydrochlorothiazide [HCTZ], torsemide), blood pressure medicine (such as enalapril, lisinopril, losartan), medicine to treat depression (such as fluoxetine), or medicine for seizures (such as carbamazepine or phenytoin).

Injectable

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle or through a needle placed in one of your veins.
• A nurse or other health provider will give you this medicine.
• This medicine is not for long-term use. It should never be used longer than 5 days.
• Missed dose: Call your doctor or pharmacist for instructions.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Ketorolac (kee-toe-ROLE-ak)

Treats pain. This medicine is an NSAID.

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, or red skin rash
• Bloody or black, tarry stools
• Change in how much or how often you urinate
• Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
• Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
• Pain in your lower leg (calf)
• Rapid weight gain, swelling in your hands, ankles, or feet
• Unusual bleeding, bruising, or weakness
• Vomiting blood or material that looks like coffee grounds

If you notice these less serious side effects, talk with your doctor:

• Diarrhea, constipation, nausea, or indigestion
• Drowsiness, dizziness, or lightheadedness
• Headache
• Pain where the shot was given

• Tell your doctor if you have kidney disease, liver disease, anemia, Crohn disease, ulcerative colitis or a history of stomach ulcers, high blood pressure, asthma, congestive heart failure, or other heart or circulation problems.
• This medicine may cause the following problems:
  • Bleeding in your stomach or intestines
  • Higher risk of heart attack or stroke
  • Serious skin reactions
  • Liver problems