Diphenoxylate/atropine (By mouth)

Lomotil

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how difenoxin/atropine works. Tell your doctor if you are using an MAO inhibitor.
• Do not drink alcohol while you are using this medicine.
• Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Liquid, Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
• Drink plenty of caffeine-free, clear liquids including ginger ale, tea, water, gelatin, or broth during the first 24 hours of treatment with this medicine.
• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Atropine Sulfate (AT-roe-peen SUL-fate), Diphenoxylate Hydrochloride (dye-fen-OX-i-late hye-droe-KLOR-ide)

Treats diarrhea.

Call your doctor right away if you notice any of these side effects:

• Blue lips, fingernails, or skin, trouble breathing
• Change in how much or how often you urinate
• Confusion, drowsiness, anxiety, changes in mood or behavior, shaky hands, problems with speech
• Extreme dizziness or weakness, shallow breathing, slow heartbeat, seizures, cold, clammy skin
• Fast or uneven heartbeat
• Severe constipation with bloating, red or black stools

If you notice these less serious side effects, talk with your doctor:

• Blurred vision
• Dry mouth
• Headache

• Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, kidney disease, stomach or bowel disease (including ulcerative colitis), or Down syndrome.
• This medicine may cause the following problems:
  • Respiratory depression (severe breathing problem)
  • Serious stomach or bowel problems (including toxic megacolon)
  • Liver problems
• This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
• This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
• Call your doctor if your symptoms do not improve or if they get worse.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.