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Hypersensitivity vasculitis

Cutaneous small vessel vasculitis; Allergic vasculitis; Leukocytoclastic vasculitis

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Causes

Hypersensitivity vasculitis, or cutaneous small vessel vasculitis, is caused by:

It usually affects people older than age 16.

Often, the cause of the problem cannot be found even with a careful study of medical history.

Hypersensitivity vasculitis may look like systemic, necrotizing vasculitis, which can affect blood vessels throughout the body and not just in the skin. In children, it can look like Henoch-Schonlein purpura.

Definition

Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and damage to blood vessels, mainly in the skin. The term is not used much currently because more specific names are considered more precise.

Exams and Tests

The health care provider will base the diagnosis on symptoms. The provider will review any medicines or drugs you have taken and recent infections. You will be asked about cough, fever, or chest pain.

A complete physical exam will be done.

Blood and urine tests may be done to look for systemic disorders such systemic lupus erythematosus, dermatomyositis, or hepatitis C. The blood tests may include:

  • Complete blood count with differential
  • Erythrocyte sedimentation rate
  • Chemistry panel with liver enzymes and creatinine
  • Antinuclear antibody (ANA)
  • Rheumatoid factor
  • Antineutrophil cytoplasmic antibodies (ANCA)
  • Complement levels
  • Cryoglobulins
  • Hepatitis B and C tests
  • HIV test
  • Urinalysis

Skin biopsy shows inflammation of the small blood vessels.

Outlook (Prognosis)

Hypersensitivity vasculitis most often goes away over time. The condition may come back in some people.

People with ongoing vasculitis should be checked for systemic vasculitis.

Possible Complications

Complications may include:

  • Lasting damage to the blood vessels or skin with scarring
  • Inflamed blood vessels affecting the internal organs

Prevention

DO NOT take medicines which have caused an allergic reaction in the past.

Symptoms

Symptoms may include:

  • New rash with tender, purple or brownish-red spots over large areas
  • Skin sores mostly located on the legs, buttocks, or trunk
  • Blisters on the skin
  • Hives (urticaria), may last longer than 24 hours
  • Open sores with dead tissue (necrotic ulcers)

Treatment

The goal of treatment is to reduce inflammation.

Your provider may prescribe aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), or corticosteroids to reduce inflammation of the blood vessels. (DO NOT give aspirin to children except as advised by your provider).

Your provider will tell you to stop taking medicines that could be causing this condition.

When to Contact a Medical Professional

Call your provider if you have symptoms of hypersensitivity vasculitis.

Review Date: 4/24/2017
Reviewed By: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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